EVENTS | VIEW CALENDAR
Automating Digital Pathology
TUCSON, Ariz. -- DMetrix, Inc., the developer of ultra-rapid, array-microscope digital imaging systems, announced that it has formed a partnership with Definiens AG, Munich, Germany. Their goal is to accelerate the development of a system that will provide completely automated digital pathology. The partners will jointly develop connectors for the new solution, which will enable drug discovery customers to benefit from the complete image capture-to-analysis process. The solution includes the DMetrix award-winning DX-40 array-microscope whole-slide scanner that captures images of slides in less than one minute, as well as the Definiens Enterprise Image Intelligence suite of products.
While the pharmaceutical industry worldwide struggles with a shortage of pathologists, the volume of diagnostic testing for new drug development has expanded. This expanded workload has increased the need for innovations that improve productivity and testing accuracy.
"The DMetrix and Definiens partnership provides the far-reaching results that the industry requires," states Rodger Brown, vice president of sales and marketing at DMetrix. "—a high-throughput, quantitative and objective tool for preclinical research to help speed the development process for new therapeutics.
"The partnership with Definiens allows us to provide a comprehensive solution to customers wanting to take advantage of the conversion of raw digital pathological data into usable, well-defined scientific information," Brown adds. "By combining the leading enterprise image intelligence platform and DMetrix's whole slide image capture instrument, we are providing an innovative system that will enhance and expedite the way preclinical studies are performed.
"Our array-microscope has the ability to capture images much faster – typically less than a minute for a standard slide but only 155 seconds for a whole slide. Other systems require 5 to 50 times longer," Brown notes. "The difference in our equipment is the ultra-rapid array lens, which is a single lens with 80 objectives. Others have to scan a slide in tiles or strips and stitch the tiles or strips together while we do the whole slide in a single pass. The DMetrix system is also the first and only multi-spectral system to produce whole slide images in up to 12 colors to provide efficient incremental analysis of multiple proteins on one slide."
The DX-40 also features topographic focus that uses a prescan to identify the topography of the tissue, and then has the ability to roll and pitch – much like an aircraft – based on the topography as it captures the image, utilizing hundreds of focal points for enhanced image quality.
Definiens' patented Cognition Network technology was developed by Nobel Laureate, Dr. Gerd Binnig, and serves as the base of the Definiens eCognition platform. The platform is designed to fulfill image analysis demands on every scale, from microscopic cell structures to satellite images.
"The partnership with DMetrix brings enormous value to our existing and future customers in the pharmaceutical industry by increasing their insight into images," says Rene Hermes, Definiens' vice president of marketing.
DMetrix's Brown estimates that the anatomical histology market, including reagents as well as equipment, totals about a $2.4 billion in annual sales and may be as large as $3.5 billion per year if the cytology piece is included. He declined to speculate about the potential sales for the new imaging system. "We expect to see a tremendous opportunity for DX-40 placement based on the unique features of the system and the partnership with Definiens for image analysis," Brown concludes.