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Prime potency
September 2019
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OTTAWA, Ontario—July ended with news from Orion Biotechnology Canada Ltd. that OB-002, its lead compound, had demonstrated in an in-vitro potency assessment that it was more potent than other CCR5 antagonists being developed for HIV prevention and cancer indications. The compound was compared against maraviroc (Selzentry or Celsentri), a small-molecule CCR5 antagonist, and PRO-140 (leronlimab), a humanized antibody CCR5 antagonist. The drugs were evaluated in two models: an aequorin-based functional inhibition assay provided by Euroscreen Fast, and an HIV replication assay from ImQuest using CCR5-tropic HIV BaL strain with PBMC from 18 healthy individuals. In the first test, OB-002 potency (0.2 nM) was 13-fold higher than that of Maraviroc (2.6 nM) and 28-fold higher than that of PRO-140/Leronlimab (5.6 nM), and in the second, OB-002’s potency was consistently higher (8- to 80-fold) than that of maraviroc.

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