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Cost-Effective Drug Permeability Screening
November 2007
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Two world-renowned companies, Tecan AG and pION Inc. have launched the PAMPA Explorer, a new manual system for drug permeability screening using the Double-Sink parallel artificial membrane permeability assay (PAMPA). Tecan is supplying its new Infinite M200 plate reader for the system. Long recognized as "the A in ADME", pION has commercialized PAMPA and developed applications that are highly correlated with Caco-2, gastrointestinal tract (GIT) and blood-brain barrier (BBB) permeation. The PAMPA Explorer is a manual, upgradeable entry-level PAMPA system featuring the Infinite M200 plate reader, capable of screening hundreds of compounds per day. The advanced quad4 monochromator technology in the Infinite M200 provides excellent sensitivity and allows the user to select any wavelength from UV to NIR, and to perform absorbance, excitation and emission scans. The PAMPA Explorer can be upgraded to a fully automated Tecan Freedom EVO platform system when sample throughput increases.  Double-Sink PAMPA is an API-sparing technique that allows the user to identify the most promising leads well in advance of other cell-based methods.
Tecan Group Ltd.
+41 44 922 81 11
pION INC
781-935 8939

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