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Automated Protein Association and Aggregation System
October 2007
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Wyatt Technology Inc., announces the launch of its Calypso automated protein association and aggregation system. This instrument package enables the rapid, quantitative, nondestructive characterization of protein-protein interactions in native solution using Composition-Gradient Multi-Angle Light Scattering (CG-MALS). With CG-MALS protein samples need not be tagged, immobilized on a surface, or otherwise modified from their natural state. It is a sensitive and precise method for the measurement of complexes and aggregates through the absolute determination of molar mass and can non-destructively characterize both weak and strong interactions. Simple or complex association stoichiometries may be analyzed, providing equilibrium dissociation constants from picomolar to millimolar, as well as self- and cross- viral coefficients and aggregation or association kinetics. The Calypso system consists of hardware and dedicated software for automating CG-MALS measurements as well as Zimm plots and dn/dc determinations. Computer-controlled syringe pumps automate the sample mixing, dilution and delivery, while intuitive software controls the experiment, acquires data and analyzes the results. The system can also be used to facilitate the study of the composition dependence of any measurable solution property (spectroscopic, hydrodynamic, calorimetric).
Wyatt Technology Inc.
805-681-9009

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