|
A full work-up for Alzheimer’s disease
December 2011
SHARING OPTIONS:
LAS VEGAS—Moving a step closer to increasing opportunities
to diagnose Alzheimer's disease before memory loss occurs, the Cleveland
Clinic’s Lou Ruvo Center for Brain Health has been chosen by Paris-based
Exonhit SA to conduct the first U.S. pilot clinical trial for AclarusDx, a
blood-based investigational diagnostic test.
Patients for this study will be recruited at three sites:
the Ruvo Center in Las Vegas; the Cleveland Clinic main campus in Cleveland,
Ohio; and Lakewood Hospital in Lakewood, Ohio. A total of 160 new patients
being seen by physicians for memory impairment will be enrolled in the trial.
The first patient was to be chosen last month.
The blood samples will be sent to biotech company Exonhit’s
Paris facility for AclarusDx test analysis.
Dr. Kate Zhong, senior director of clinical research
development at the Ruvo Center, says being able to diagnose Alzheimer’s disease
early is vital as more baby boomers become senior citizens and people live
longer than expected.
About half of Americans over the age of 85 will get
Alzheimer's disease, she says. Also, an estimated 5.4 million Americans have
Alzheimer's disease, with that number expected to increase to 16 million by
2050. If trends continue, Alzheimer's will cost taxpayer-supported Medicare and
Medicaid $20 trillion by 2050, according to an Alzheimer's Study Group report
released last year.
If the trials are successful and the specific blood test can
diagnose Alzheimer's, this will provide a quick, less invasive and affordable
means to diagnose Alzheimer’s at an early stage, Zhong says.
Currently, an Alzheimer’s diagnosis is based on psychometric
tests and behavior evaluations, as well as brain imaging at a stage of the
dementia where the onset of the disease has already started, reports Exonhit.
Early, accurate and reliable diagnostic tools are essential to improve patient
management and therapeutic treatments. The use of AclarusDx could help
accelerate the full diagnostic workup.
The Cleveland Clinic Alzheimer’s trial consortium “is one of the leading Alzheimer’s
trial organizations,” Zhong tells ddn.
“We are ideally positioned to provide the large volume of trials participants,
rapid start-up, with one IRB, one contract, one budget and Cleveland Clinic
SOP.”
Individuals chosen for the study will be “patients who have
memory complaints, patients who visit their primary care provider for a
diagnostic work up,” she says. “There is no age limitation; it could be anyone
who has a perceived memory problem.
“Alzheimer’s does have a genetic component,” Zhong adds.
“Those who carry APOE 4 genes have a much higher likelihood of having
Alzheimer’s compared to those who don't.”
Two successful trials on patients in France using the
AclarusDx test have proven successful, according to Exonhit.
“If successful, the findings from this trial will aid
physicians for early detection and early treatment in this population,” Zhong
says. “The goal is to obtain FDA approval on the utilization of AclarusDx as
the diagnostic assay for Alzheimer's disease.”
Dr. Loïc Maurel, president of Exonhit’s management board
stated, “Knowing that 5.4 million Americans are living with Alzheimer’s and
that the disease costs $183 billion per year, significant efforts have to be
made to identify Alzheimer’s at its very early stages to improve the management
of the disease. Our ultimate goal is to define the clinical utility of
AclarusDx to provide primary care physicians with a diagnostic tool that will
help them identify patients at high risk of having Alzheimer’s and to prescribe
a complete diagnostic workup.”
Exonhit extends strategic collaboration with Allergan
PARIS—ExonHit SA also announced in November the extension of
its existing drug discovery collaboration with Allergan Sales LLC. The
collaboration was initiated in December 2002 and extended several times. It now
is further extended until December 2013.
The collaboration will continue to focus on the
identification, development and commercialization of drugs for the treatment of
neurodegenerative diseases, pain and ophthalmology.
“We are very pleased that our longstanding strategic
collaboration with Allergan will continue until the end of 2013. The
collaboration has created significant value for both organizations, and we are
optimistic that it will continue to build upon recent successes and advance
additional existing preclinical programs into clinical development,” said Loïc
Maurel, CEO of Exonhit, in a statement.
Detailed financial terms were not disclosed. Code: E121114 Back |
|
||
|
Home |
FAQs |
Search |
Submit News Release |
Site Map |
About Us |
Advertising |
Resources |
Contact Us |
Terms & Conditions |
Privacy Policy
|