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Abcam signs license agreement with Columbia
May 2013
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BRISTOL, United Kingdom—An exclusive license agreement was inked in early April between Abcam PLC and Columbia University for two novel pH-responsive fluorescent false neurotransmitters (FFNs), FFN102 and FFN202. Per the agreement, Abcam Biochemicals will provide the FFN compounds to its customers to support fundamental and applied neurobiological research. The two molecules are compatible with GFP tags, and are sufficiently bright, photostable and suitable for two-photo and standard fluorescence microscopy. These probes serve as optical tracers, enabling imaging of neurotransmitter release from individual presynaptic terminals in the human brain. FFN102 enables the measurement of dopamine synapse activity and further study of synaptic plasticity through optical imaging of dopaminergic presynaptic terminals. FFN202 can be used in screening drugs to determine their effects on the pH of secretory vesicles.

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