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Monoclonal Antibody Purification, GE Healthcare
July 2006
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HiTrap MabSelect, HiTrap MabSelect Xtra, and HiTrap MabSelect SuRe (for Superior Resistance) are members of the HiTrap family of prepacked columns for purification of monoclonal antibodies (MAbs). Designed for lab-scale use, screening of purification conditions, and process development, these 1-mL and 5-mL columns offer high binding capacity and convenient use with a syringe, a laboratory pump, or a chromatography system, such as ─KTAdesign. MabSelect Xtra is a member of the MabSelectTM product line of recombinant protein A-based affinity media for capturing monoclonal antibodies. Like its companion product, MabSelect, Mab Select Xtra is based on a unique high flow agarose-based matrix, optimized for maximum capacity. The recombinant protein A is coupled to the base matrix at the C-terminal cysteine via a stable thio-ether bond. It is the same ligand and coupling chemistry used in MabSelect. This oriented coupling contributes to the increased capacity seen with these media. The MabSelect SuRe columns may be reused when combined with the ─KTAxpress Mab, utilizing pre-programmed cleaning in place (CIP) protocols to avoid sample cross contamination while simultaneously maintaining the high binding capacity of the MabSelect media.
 
GE Healthcare
800.526.3593
www.gehealthcare.com/hitrap

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