Here are just a few editorial highlights from the DDNews Cancer Research News site and other online vehicles of DDNews magazine to get you acquainted with the website and show you the range of our coverage.

By Dr. Dragan Cicic, Actinium Pharmaceuticals Inc.
Patients with blood cancers often face poor long-term survival outcomes, but a new treatment approach could offer more effective targeting of cancer cells as well as lower toxicity.
By Kelsey Kaustinen, DDNews Senior Editor
If all milestones are met, the agreement could be worth up to $817 million
By Jeffrey Bouley, DDNews Chief Editor
Multiple Myeloma Research Foundation announces six new clinical trials in 2014, and Cellectar Biosciences announces IND for relapsed or refractory multiple myeloma drug
By Lloyd Dunlap, DDNews Managing Editor
Service center will allow the expansion of new immunotherapy experimental platforms to advance translational medical research and the treatment of cancers
DDNews Cancer Research Exclusive: Turning an eye to TERT
By Kelsey Kaustinen, DDNews Senior Editor
As part of the TCGA initiative, researchers have discovered multiple cases of missing chromosomes in chromophobe renal cell carcinoma, as well as rearrangements in the promoter region of the TERT gene
Biodesix in Phase III trial collaboration with Kadmon
April 2012

BOULDER, Colo.—Biodesix Inc., a fully integrated molecular diagnostic company dedicated to personalizing medicine, announced last month a collaboration with Kadmon Corp. LLC to explore the utility of Biodesix's VeriStrat test in a Phase III non-small cell lung cancer (NSCLC) study of Kadmon's KD019, a reversible tyrosine kinase inhibitor (TKI) targeting EGFR, HER2, VEGFR2 & 3 and SRC.  
The Phase III study is designed to evaluate KD019 compared to erlotinib in patients with stage IIIB/IV NSCLC who have progressed after first- or second-line chemotherapy. It incorporates an exploratory analysis using VeriStrat, a commercially available, blood-based test that is currently used to help physicians guide treatment for patients with non-small cell lung cancer. VeriStrat testing will be performed on serum samples from the study to assess the test's utility in identifying patients with better or worse outcomes following treatment with KD019. As a multiple TKI with superior potency against wild-type EGFR, KD019 is designed to improve overall survival compared to erlotinib.  
"We are very pleased to work with Kadmon on this program," says Dr. Paul Beresford, Biodesix's vice president of business development and strategic marketing. "Our successful collaboration may bring a personalized approach to this exciting new therapy."
Over the past year, Biodesix has forged multiple partnerships with biopharmaceutical companies to examine VeriStrat's utility with innovative oncology therapies and to discover novel diagnostic tests.  
"This collaboration is aligned with our strategic vision to advance leading-edge science and therapies targeting multiple pathways of proliferation and survival in disease," says Dr. John Ryan, chief medical officer of Kadmon.


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