AMSBIO Lipidure-Coat low-adhesion plates and dishes are shown in cited research to be one of the most effective tools for state-of-the-art 3D spheroid cell culture. These new plates and dishes are available in 384-well format optimized for drug screening or other high-throughput applications.

 

Lipidure-Coat surfaces use MPC (2-methacryloyloxtethyl phosphorylcholine), a biocompatible synthetic polymer with the same structure as the phosphorylcholine polar bases that form cell membranes. As a consequence of the high biocompatibility of this coating, cells will not adhere to the surface of Lipidure-Coat plates or dishes. Different well-shapes available for 96-well plates (U, V and flat-bottom) can be used to control size, position and density of spheroids. Studies have shown that Lipidure-Coat promotes the formation of a single spheroid in each well of U-bottom multi-well plate, while other brands of plate lead to formation of satellite spheroids, indicating a higher degree of cell adhesion is taking place.

 

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