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Researchers prove iPS cells capable of
mirroring disease
February 2012
SHARING OPTIONS:
STANFORD, Calif.—Researchers at the Stanford
University
School of Medicine have found that induced pluripotent stem cells (iPS), which
are a popular alternative to embryonic stem cells, are
capable of mirroring the
defining defects of a genetic condition as well as embryonic stem cells can.
The discovery was made while working with Marfan
syndrome, and the success
means that iPS cells could be used to examine the molecular aspects of the disorder
on a personalized basis, something that
is impossible with embryonic stem cells
as their contents are those of the embryo, not the patient.
"Our in-vitro
findings strongly point to the underlying mechanisms that may explain the
clinical manifestations of Marfan syndrome," Dr. Michael Longaker, professor
of
surgery and senior author of the study, said in a press release. Back |
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