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Researchers prove iPS cells capable of mirroring disease
February 2012
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STANFORD, Calif.—Researchers at the Stanford University School of Medicine have found that induced pluripotent stem cells (iPS), which are a popular alternative to embryonic stem cells, are capable of mirroring the defining defects of a genetic condition as well as embryonic stem cells can. The discovery was made while working with Marfan syndrome, and the success means that iPS cells could be used to examine the molecular aspects of the disorder on a personalized basis, something that is impossible with embryonic stem cells as their contents are those of the embryo, not the patient.   "Our in-vitro findings strongly point to the underlying mechanisms that may explain the clinical manifestations of Marfan syndrome," Dr. Michael Longaker, professor of surgery and senior author of the study, said in a press release.

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